In 1936, the curriculum emphasis shifted to rural teacher education; students were able to receive professional teaching certificates after completing a third academic year. 

The first baccalaureate degree was awarded in 1944, in elementary education. In 1946, the school became Grambling College, named after P.G. Grambling, the white sawmill owner who had donated the parcel of land where the school was constructed. In addition to elementary educators, Grambling prepared secondary teachers and added curricula in sciences, liberal arts and business, transforming the college from a single purpose institution of teacher education into a multipurpose college. In 1949, the college earned its first accreditation by the Southern Association of Colleges and Schools (SACS).

In 1974, the addition of graduate programs in early childhood and elementary education gave the school a new status and a new name – Grambling State University. The university expanded and prospered between 1977 and 2000. Several new academic programs were incorporated and new facilities were added to the 384-acre campus, including a business and computer science building, school of nursing, student services building, stadium, stadium support facility and an intramural sports center.